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通过拉动单链能解开双链DNA吗?:吸附DNA的阶段。

Can a double stranded DNA be unzipped by pulling a single strand?: phases of adsorbed DNA.

作者信息

Kapri Rajeev

机构信息

Department of Theoretical Physics, Tata Institute of Fundamental Research, 1 Homi Bhabha Road, Mumbai 400 005 India.

出版信息

J Chem Phys. 2009 Apr 14;130(14):145105. doi: 10.1063/1.3116082.

Abstract

We study the unzipping of a double stranded DNA (dsDNA) by applying an external force on a single strand while leaving the other strand free. We find that the dsDNA can be unzipped to two single strands if the external force exceeds a critical value. We obtain the phase diagram, which is found to be different from the phase diagram of unzipping by pulling both the strands in opposite directions. In the presence of an attractive surface near DNA, the phase diagram gets modified drastically and shows richer surprises including a critical end point and a triple point.

摘要

我们通过对单链施加外力而让另一条链自由的方式来研究双链DNA(dsDNA)的解链过程。我们发现,如果外力超过一个临界值,双链DNA可以解链为两条单链。我们得到了相图,发现它与通过向相反方向拉动两条链来解链的相图不同。在DNA附近存在吸引表面的情况下,相图会发生剧烈变化,并展现出更丰富的意外情况,包括一个临界端点和一个三相点。

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