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Biochemistry: Anchors away.

作者信息

Costi Maria Paola, Ferrari Stefania

出版信息

Nature. 2009 Apr 16;458(7240):840-1. doi: 10.1038/458840a.

DOI:10.1038/458840a

PMID:19370021

Abstract

摘要

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本文引用的文献

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.

Nature. 2009 Apr 16;458(7240):919-23. doi: 10.1038/nature07973.

Design, synthesis and evaluation of potent thymidylate synthase X inhibitors.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3628-31. doi: 10.1016/j.bmcl.2008.04.080. Epub 2008 May 6.

Mechanistic studies of a flavin-dependent thymidylate synthase.

Biochemistry. 2004 Aug 17;43(32):10295-301. doi: 10.1021/bi0490439.

Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.

Proc Natl Acad Sci U S A. 2004 May 11;101(19):7252-7. doi: 10.1073/pnas.0401365101. Epub 2004 Apr 27.

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. doi: 10.1073/pnas.142413399. Epub 2002 Aug 22.

An alternative flavin-dependent mechanism for thymidylate synthesis.

Science. 2002 Jul 5;297(5578):105-7. doi: 10.1126/science.1072113. Epub 2002 May 23.

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相似文献

Biochemistry: Anchors away.

Nature. 2009 Apr 16;458(7240):840-1. doi: 10.1038/458840a.

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.

Nature. 2009 Apr 16;458(7240):919-23. doi: 10.1038/nature07973.

Biochemistry. DNA building block reinvented.

Science. 2002 Jul 5;297(5578):61-2. doi: 10.1126/science.1073910. Epub 2002 May 23.

A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link.

Chem Commun (Camb). 2006 Apr 28(16):1781-3. doi: 10.1039/b517881a. Epub 2006 Mar 17.

An alternative flavin-dependent mechanism for thymidylate synthesis.

Science. 2002 Jul 5;297(5578):105-7. doi: 10.1126/science.1072113. Epub 2002 May 23.

Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution.

J Mol Biol. 2005 Oct 7;352(5):1091-104. doi: 10.1016/j.jmb.2005.07.071.

Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1.

Protein Sci. 2011 Aug;20(8):1398-410. doi: 10.1002/pro.668. Epub 2011 Jul 6.

Enzyme Activation with a Synthetic Catalytic Co-enzyme Intermediate: Nucleotide Methylation by Flavoenzymes.

Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12523-12527. doi: 10.1002/anie.201706219. Epub 2017 Sep 5.

Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein.

Structure. 2003 Jun;11(6):677-90. doi: 10.1016/s0969-2126(03)00097-2.

Crystal structure of a flavin-dependent thymidylate synthase from Helicobacter pylori strain 26695.

Protein Pept Lett. 2012 Nov;19(11):1225-30. doi: 10.2174/092986612803217105.

引用本文的文献

Folate binding site of flavin-dependent thymidylate synthase.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15722-7. doi: 10.1073/pnas.1206077109. Epub 2012 Sep 10.

Flavin-dependent thymidylate synthase: a novel pathway towards thymine.

Arch Biochem Biophys. 2010 Jan 1;493(1):96-102. doi: 10.1016/j.abb.2009.07.016. Epub 2009 Jul 28.

本文引用的文献

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene.

Nature. 2009 Apr 16;458(7240):919-23. doi: 10.1038/nature07973.

Design, synthesis and evaluation of potent thymidylate synthase X inhibitors.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3628-31. doi: 10.1016/j.bmcl.2008.04.080. Epub 2008 May 6.

Mechanistic studies of a flavin-dependent thymidylate synthase.

Biochemistry. 2004 Aug 17;43(32):10295-301. doi: 10.1021/bi0490439.

Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.

Proc Natl Acad Sci U S A. 2004 May 11;101(19):7252-7. doi: 10.1073/pnas.0401365101. Epub 2004 Apr 27.

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. doi: 10.1073/pnas.142413399. Epub 2002 Aug 22.

An alternative flavin-dependent mechanism for thymidylate synthesis.

Science. 2002 Jul 5;297(5578):105-7. doi: 10.1126/science.1072113. Epub 2002 May 23.