三氯化锑催化的直接三组分一锅法曼尼希反应。

Antimony(III) chloride catalyzed direct three component one-pot Mannich reaction.

作者信息

Shukla Prashant, Chattopadhyay Nilmadhab, Nayak Sandip K

机构信息

Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai-400085, India.

出版信息

Nat Prod Commun. 2009 Feb;4(2):247-50.

PMID:19370932

Abstract

Antimony(III) chloride catalyzes the three component Mannich type reaction of a variety of in-situ generated Schiff bases generated from aromatic aldehydes and anilines with cyclic/acyclic ketones. The reaction proceeds smoothly at ambient temperature to afford the corresponding beta-amino ketones in good yields with moderate to good diastereoselectivity.

摘要

三氯化锑催化由芳香醛和苯胺生成的多种原位席夫碱与环状/非环状酮的三组分曼尼希型反应。该反应在室温下顺利进行，以中等至良好的非对映选择性，高收率得到相应的β-氨基酮。