来自哥斯达黎加蒙特维德的毛枝树参、山地南美参和罗氏鹅掌柴的精油成分及细胞毒性活性

Essential oil compositions and cytotoxic activities of Dendropanax capillaris, Oreopanax nubigenus, and Schefflera rodrigueziana from Monteverde, Costa Rica.

作者信息

Richmond Justin D, Agius Brittany R, Wright Brenda S, Haber William A, Moriarity Debra M, Setzer William N

机构信息

Department of Chemistry, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA.

出版信息

Nat Prod Commun. 2009 Feb;4(2):271-4.

PMID:19370937

Abstract

The leaf essential oils of Dendropanax capillaris, Oreopanax nubigenus and Schefflera rodrigueziana (Araliaceae) were isolated by hydrodistillation and analyzed by GC-MS. The leaf oil of Dendropanax capillaris was composed of only four compounds, beta-pinene (25.3%), 6-3-carene (44.7%), daucene (17.1%), and dauca-5,8-diene (12.9%). Oreopanax nubigenus leaf oil was dominated by the sesquiterpene hydrocarbons germacrene D (70.1%) and beta-caryophyllene (11.8%), while Schefflera rodrigueziana leaf oil was made up entirely of sesquiterpene hydrocarbons, mostly germacrene D (27.6%), beta-cubebene (27.2%), beta-caryophyllene (12.2%), beta-cubebene (11.1%), and alpha-copaene (10.8%). Both O. nubigenus and S. rodrigueziana leaf oils showed notable in-vitro cytotoxicity on MDA-MB-231 cells, which may be attributable to the relatively high concentrations of germacrene D and beta-caryophyllene in those oils.

摘要

通过水蒸馏法分离了细柱树参、云雾南美参和罗氏鹅掌柴（五加科）的叶精油，并采用气相色谱-质谱联用仪（GC-MS）进行分析。细柱树参的叶油仅由四种化合物组成，即β-蒎烯（25.3%）、6-3-蒈烯（44.7%）、胡萝卜素（17.1%）和胡萝卜-5,8-二烯（12.9%）。云雾南美参叶油以倍半萜烃类杜松烯D（70.1%）和β-石竹烯（11.8%）为主，而罗氏鹅掌柴叶油则完全由倍半萜烃类组成，主要是杜松烯D（27.6%）、β-荜澄茄烯（27.2%）、β-石竹烯（12.2%）、β-荜澄茄烯（11.1%）和α-可巴烯（10.8%）。云雾南美参和罗氏鹅掌柴的叶油对MDA-MB-231细胞均表现出显著的体外细胞毒性，这可能归因于这些油中相对较高浓度的杜松烯D和β-石竹烯。