感染与自身免疫中的人类辅助性T细胞17

Human Th17 cells in infection and autoimmunity.

作者信息

Sallusto Federica, Lanzavecchia Antonio

机构信息

Institute for Research in Biomedicine, Bellinzona, Switzerland.

出版信息

Microbes Infect. 2009 Apr;11(5):620-4. doi: 10.1016/j.micinf.2009.04.004. Epub 2009 Apr 14.

DOI:10.1016/j.micinf.2009.04.004

PMID:19371794

Abstract

IL-17-producing T cells (Th17) have been identified in mice as a distinct lineage of CD4(+) T helper cells. Since their discovery, efforts have been made in characterizing human Th17 cells and the factors involved in their differentiation and in understanding the role these cells play in protective immunity and autoimmune diseases.

摘要

在小鼠中，产生白细胞介素-17的T细胞（Th17）已被鉴定为CD4(+)辅助性T细胞的一个独特谱系。自发现以来，人们一直在努力表征人类Th17细胞及其分化过程中涉及的因子，并了解这些细胞在保护性免疫和自身免疫性疾病中所起的作用。