首先是磷酸肌醇与钙离子信号传导之间的联系，接着是大量其他的磷酸肌醇功能被发现。

First came the link between phosphoinositides and Ca2+ signalling, and then a deluge of other phosphoinositide functions.

作者信息

Michell Robert H

机构信息

School of Biosciences, University of Birmingham, Birmingham, UK.

出版信息

Cell Calcium. 2009 Jun;45(6):521-6. doi: 10.1016/j.ceca.2009.03.007. Epub 2009 Apr 15.

DOI:10.1016/j.ceca.2009.03.007

PMID:19371949

Abstract

The link between phosphoinositide turnover and Ca(2+)-regulated cell processes goes back half a century, but only began to be understood in the 1970s. This article briefly outlines how the roles of these minority membrane lipids in Ca(2+) signalling and then in multifarious other biological processes were recognised during the latter half of the 20th century.

摘要

磷酸肌醇代谢与钙离子调节的细胞过程之间的联系可以追溯到半个世纪前，但直到20世纪70年代才开始被人们所理解。本文简要概述了在20世纪后半叶，这些少量膜脂在钙离子信号传导以及随后在各种其他生物过程中的作用是如何被认识的。