Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Curr Opin HIV AIDS. 2006 May;1(3):194-9. doi: 10.1097/01.COH.0000221591.11294.c1.
The immediate events in HIV-1 infection following fusion of HIV-1 particles with the target cells are poorly defined and difficult to study. It is generally thought that the viral capsid undergoes a disassembly process that has broadly been referred to as uncoating. The recent identification of species-specific host restriction factors that target the viral capsid has sparked new interest in retroviral uncoating.
Recent studies have used purified HIV-1 cores to study HIV-1 uncoating in vitro. This review summarizes the recent literature relevant to HIV-1 uncoating with a specific emphasis on viral and cellular factors that may regulate capsid stability.
Uncoating of the viral core is a key step in the infection of HIV-1 that is highly sensitive to alterations in capsid stability. The uncoating step of HIV-1 infection may thus represent an attractive target for the development of novel antiretroviral therapies.
HIV-1 感染后，HIV-1 颗粒与靶细胞融合，其即刻事件定义不明确，难以研究。人们普遍认为，病毒衣壳经历了一个广泛称为脱壳的解体过程。最近发现的针对病毒衣壳的种属特异性宿主限制因子，激发了人们对逆转录病毒脱壳的新兴趣。
最近的研究使用纯化的 HIV-1 核心来研究体外的 HIV-1 脱壳。本综述总结了与 HIV-1 脱壳相关的最新文献，特别强调了可能调节衣壳稳定性的病毒和细胞因素。
病毒核心的脱壳是 HIV-1 感染的关键步骤，其对衣壳稳定性的改变高度敏感。因此，HIV-1 感染的脱壳步骤可能成为开发新型抗逆转录病毒疗法的有吸引力的靶点。
