Erdmann E
Medizinische Klinik I, Universität München.
Fortschr Med. 1991 Aug 30;109(25):488-91.
Holter monitoring has revealed that bradycardiac and tachycardic arrhythmias are frequent in apparently healthy subjects aged over 75. Even in elderly patients with known cardiovascular disease, however, such arrhythmias usually do not correlate with the clinical symptoms giddiness, palpitations or syncope. For this reason, prior to possible therapeutic measures, an accurate investigation of the underlying cause and the demonstration of a causal relationship between documented arrhythmias and symptomatology is necessary. Account must be taken of the particular pharmacotherapeutic situation in old age, in which the pharmacokinetics and pharmacodynamic properties of almost all drugs are modified.
动态心电图监测显示,75岁以上看似健康的人群中,缓慢性和快速性心律失常很常见。然而,即使在患有已知心血管疾病的老年患者中,此类心律失常通常也与头晕、心悸或晕厥等临床症状无关。因此,在采取可能的治疗措施之前,有必要对潜在病因进行准确调查,并证明所记录的心律失常与症状之间存在因果关系。必须考虑老年患者特殊的药物治疗情况,几乎所有药物的药代动力学和药效学特性在老年患者中都会发生改变。