[癫痫或热性惊厥患儿的血清褪黑素水平]

[Serum melatonin levels in children with epilepsy or febrile seizures].

作者信息

Guo Jing-Fang, Yao Bao-Zhen

机构信息

Department of Pediatrics, People's Hospital of Wuhan University, Wuhan 430060, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2009 Apr;11(4):288-90.

PMID:19374814

Abstract

OBJECTIVE

To study serum levels of melatonin in children with epilepsy or febrile seizures in order to provide a basis for the treatment of epilepsy or febrile seizures with melatonin.

METHODS

Serum melatonin levels were measured using ELISA in 15 children with simple febrile seizure (SFS), in 15 children with complex febrile seizure (CFS), in 15 children with epilepsy, and in 15 children with upper respiratory infections (control group).

RESULTS

Serum melatonin levels in children with epilepsy (8.66+/-1.38 ng/L) or CFS (14.91+/-2.61 ng/L) were significant lower than those in the control group (23.93+/-2.01 ng/L) (P<0.01). The SFS group showed lower serum melatonin levels (20.72+/-2.54 ng/L) compared with the control group, but there were no statistical differences between the two groups. Serum melatonin levels in the epilepsy group were significantly lower than those in the CFS (P<0.05) and the SFS groups (P<0.01).

CONCLUSIONS

Serum melatonin levels decreased in children with epilepsy or CFS. Supplement of exogenous melatonin might be a promising treatment for epilepsy and febrile seizures in children.

摘要

目的

研究癫痫或热性惊厥患儿血清褪黑素水平，为褪黑素治疗癫痫或热性惊厥提供依据。

方法

采用酶联免疫吸附测定法（ELISA）检测15例单纯热性惊厥（SFS）患儿、15例复杂性热性惊厥（CFS）患儿、15例癫痫患儿及15例上呼吸道感染患儿（对照组）的血清褪黑素水平。

结果

癫痫患儿（8.66±1.38 ng/L）和CFS患儿（14.91±2.61 ng/L）的血清褪黑素水平显著低于对照组（23.93±2.01 ng/L）（P<0.01）。SFS组血清褪黑素水平（20.72±2.54 ng/L）低于对照组，但两组间无统计学差异。癫痫组血清褪黑素水平显著低于CFS组（P<0.05）和SFS组（P<0.01）。