非典型瞬时受体电位通道的磷酸肌醇调节
Phosphoinositide regulation of non-canonical transient receptor potential channels.
作者信息
Rohacs Tibor
机构信息
UMDNJ - New Jersey Medical School, Newark, NJ, USA.
出版信息
Cell Calcium. 2009 Jun;45(6):554-65. doi: 10.1016/j.ceca.2009.03.011. Epub 2009 Apr 18.
Abstract
Transient receptor potential (TRP) channels are involved in a wide range of physiological processes, and characterized by diverse activation mechanisms. Phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PIP(2), or PtdIns(4,5)P(2)] recently emerged as regulators of many TRP channels. Several TRP channels require PIP(2) for activity, and depletion of the lipid inhibits them. For some TRP channels, however, phosphoinositide regulation seems more complex, both activating and inhibitory effects have been reported. This review will discuss phosphoinositide regulation of members of the TRPM (Melastatin), TRPV (Vanilloid), TRPA (Ankyrin) and TRPP (Polycystin) families. Lipid regulation of TRPC (Canonical) channels is discussed elsewhere in this volume.
摘要
瞬时受体电位（TRP）通道参与多种生理过程，其特点是激活机制多样。磷酸肌醇，尤其是磷脂酰肌醇4,5-二磷酸[PIP(2)，或PtdIns(4,5)P(2)]最近成为许多TRP通道的调节因子。几种TRP通道的活性需要PIP(2)，脂质的耗尽会抑制它们。然而，对于一些TRP通道，磷酸肌醇调节似乎更为复杂，既有激活作用也有抑制作用的报道。本综述将讨论TRPM（褪黑素）、TRPV（香草酸）、TRPA（锚蛋白）和TRPP（多囊蛋白）家族成员的磷酸肌醇调节。TRPC（典型）通道的脂质调节在本卷其他地方讨论。
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