Thayer Julian F
Department of Psychology, 133 Psychology Building, 1835 Neil Ave., Columbus, OH 43210, USA.
Cleve Clin J Med. 2009 Apr;76 Suppl 2:S23-6. doi: 10.3949/ccjm.76.s2.05.
Inhibition of sympathoexcitatory circuits is influenced by cerebral structures and mediated via vagal mechanisms. Studies of pharmacologic blockade of the prefrontal cortex together with neuroimaging studies support the role of the right hemisphere in parasympathetic control of the heart via its connection with the right vagus nerve. Neural mechanisms also regulate inflammation; vagus nerve activity inhibits macrophage activation and the synthesis of tumor necrosis factor in the reticuloendothelial system through the release of acetylcholine. Data suggest an association between heart rate variability and inflammation that may support the concept of a cholinergic anti-inflammatory pathway.
交感神经兴奋回路的抑制受脑结构影响，并通过迷走神经机制介导。前额叶皮质的药理学阻断研究以及神经影像学研究支持右半球通过与右迷走神经的连接在心脏副交感神经控制中的作用。神经机制也调节炎症；迷走神经活动通过释放乙酰胆碱抑制巨噬细胞活化和网状内皮系统中肿瘤坏死因子的合成。数据表明心率变异性与炎症之间存在关联，这可能支持胆碱能抗炎途径的概念。
