大鼠颅骨内的聚合物凝胶，用于评估一种与伽玛刀配套使用的新型大鼠立体定向装置的准确性。
Polymer gel in rat skull to assess the accuracy of a new rat stereotactic device for use with the Gamma Knife.
作者信息
Charest Gabriel, Mathieu David, Lepage Martin, Fortin David, Paquette Benoit, Sanche Léon
机构信息
Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H5H3, Canada.
出版信息
Acta Neurochir (Wien). 2009 Jun;151(6):677-83; discussion 683-4. doi: 10.1007/s00701-009-0298-1. Epub 2009 Apr 18.
PURPOSE
Accurate targeting is crucial for the irradiation of a small-volume animal brain. We propose an original method, based on a polymer gel, to determine the accuracy and reproducibility of irradiation using a new stereotactic frame.
METHODS
An in-house designed rat stereotactic frame, compatible with the Gamma Knife, was constructed. The rat brain was then removed through a small burr hole and the intracranial cavity was washed and filled with a polymer gel. This "gel brain" was irradiated by Gamma Knife and the irradiated volumes and coordinates were measured after the irradiation.
RESULTS
The position of the polymerized areas revealed that the stereotactic frame was able to accurately reproduce the same position of irradiation in each animal. The small standard deviation demonstrated the high reproducibility.
CONCLUSION
The polymer gel confirmed the ability of the rat stereotactic frame to accurately and reproducibly position a small animal for precise radiosurgery procedures.
目的
精确靶向对于小体积动物脑部的放射治疗至关重要。我们提出了一种基于聚合物凝胶的原创方法，以使用新型立体定向框架来确定放射治疗的准确性和可重复性。
方法
构建了一种内部设计的、与伽玛刀兼容的大鼠立体定向框架。然后通过一个小钻孔移除大鼠脑部，并冲洗颅内腔并填充聚合物凝胶。该“凝胶脑”接受伽玛刀照射，照射后测量照射体积和坐标。
结果
聚合区域的位置表明，立体定向框架能够在每只动物中准确重现相同的照射位置。小的标准差证明了高可重复性。
结论
聚合物凝胶证实了大鼠立体定向框架能够准确且可重复地定位小动物以进行精确的放射外科手术。
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