Lee Hyun Joo, Park Seung-Il, Kim Dong Kwan, Kim Yong Hee
Department of Thoracic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Ann Thorac Surg. 2009 May;87(5):1569-71. doi: 10.1016/j.athoracsur.2009.01.051.
Due to the rarity of esophageal gastrointestinal stromal tumors (GISTs), their clinical course and treatment are poorly understood. We have assessed our experience in the diagnosis and management of esophageal GISTs.
We performed a retrospective chart review of patients diagnosed with esophageal GISTs who underwent surgical resection.
We identified 7 patients (6 males and 1 female) who underwent surgical procedures due to esophageal GISTs between 2001 and 2003; their median age was 46 years (range, 39 to 68 years). Four patients presented with dysphagia. Two patients were diagnosed with GIST by endoscopic biopsy before surgery. Five patients underwent enucleation, and two underwent esophagectomy. All tumors were resected completely and no patient received perioperative imatinib therapy. Median postoperative follow-up was 4.4 years (range, 2.2 to 7.0 years), during which two patients were diagnosed with recurrences.
Esophageal GIST is a rare disease, and complete surgical resection is the standard treatment. Regular follow-up is needed even if resection is complete and negative margins are achieved.
由于食管胃肠道间质瘤（GIST）罕见，其临床病程及治疗方法尚不清楚。我们评估了在食管GIST诊断和管理方面的经验。
我们对诊断为食管GIST并接受手术切除的患者进行了回顾性病历审查。
我们确定了7例患者（6例男性和1例女性），他们在2001年至2003年期间因食管GIST接受了手术；他们的中位年龄为46岁（范围39至68岁）。4例患者出现吞咽困难。2例患者在手术前通过内镜活检诊断为GIST。5例患者接受了摘除术，2例接受了食管切除术。所有肿瘤均被完全切除，且无患者接受围手术期伊马替尼治疗。术后中位随访时间为4.4年（范围2.2至7.0年），在此期间，2例患者被诊断为复发。
食管GIST是一种罕见疾病，完整手术切除是标准治疗方法。即使切除完整且切缘阴性，也需要定期随访。
