急性髓系白血病伴尿崩症及7号染色体单体。
Acute myeloid leukemia and diabetes insipidus with monosomy 7.
作者信息
Harb Antoine, Tan Wei, Wilding Gregory E, Battiwalla Minoo, Sait Sheila N J, Wang Eunice S, Wetzler Meir
机构信息
Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
出版信息
Cancer Genet Cytogenet. 2009 Apr 15;190(2):97-100. doi: 10.1016/j.cancergencyto.2009.01.006.
The predisposition of monosomy 7 to diabetes insipidus (DI) in acute myeloid leukemia (AML) led us to ask whether AML associated with monosomy 7 and DI will differ from AML associated with other karyotype aberrations and DI and whether the outcome of patients with AML and DI will differ from those without DI. We describe 2 patients from Roswell Park Cancer Institute and discuss 29 additional cases from the literature. AML with monosomy 7 and DI (n = 25) had a trend towards a lower complete remission (p = 0.0936) and worse survival (p = 0.0480) than AML with other karyotype changes and DI (n = 6). Further, AML with monosomy 7 and DI had worse complete remission rate and overall survival than AML with monosomy 7 but without DI. In conclusion, it appears that AML with monosomy 7 and DI is a disease entity with specifically poor outcome.
7号染色体单体在急性髓系白血病（AML）中易引发尿崩症（DI），这促使我们思考，伴有7号染色体单体和DI的AML是否与伴有其他核型异常及DI的AML有所不同，以及AML合并DI的患者预后是否与不合并DI的患者不同。我们描述了罗斯威尔帕克癌症研究所的2例患者，并讨论了文献中另外29例病例。与伴有其他核型改变及DI的AML（n = 6）相比，伴有7号染色体单体和DI的AML（n = 25）完全缓解率有降低趋势（p = 0.0936）且生存率更差（p = 0.0480）。此外，伴有7号染色体单体和DI的AML比伴有7号染色体单体但无DI的AML完全缓解率更差，总生存期更短。总之，伴有7号染色体单体和DI的AML似乎是一种预后特别差的疾病实体。
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