人人为我，我为人人：疱疹病毒微小RNA锁定其猎物。

All for one and one for all: herpesviral microRNAs close in on their prey.

作者信息

Dölken Lars, Jonjic Stipan

机构信息

Max von Pettenkofer-Institut, Pettenkoferstrasse 9a, München D-80336, Germany.

出版信息

Cell Host Microbe. 2009 Apr 23;5(4):315-7. doi: 10.1016/j.chom.2009.03.009.

DOI:10.1016/j.chom.2009.03.009

PMID:19380110

Abstract

Herpesviruses subvert immune cell activation by inhibiting NK cell receptor (NKG2D)-activating ligands such as MICB. A human cytomegalovirus microRNA was recently shown to repress MICB expression. Nachmani et al. (2009) extend this finding to two other human herpesviruses, providing evidence for a conserved functional role of viral microRNAs despite no sequence conservation among them.

摘要

疱疹病毒通过抑制自然杀伤细胞受体（NKG2D）激活配体（如MICB）来破坏免疫细胞的激活。最近有研究表明，一种人类巨细胞病毒微小RNA可抑制MICB的表达。纳赫马尼等人（2009年）将这一发现扩展到另外两种人类疱疹病毒，证明了病毒微小RNA尽管在序列上没有保守性，但仍具有保守的功能作用。