Testori Alessandro, Soteldo Javier, Sances Daniele, Mazzarol Giovanni, Trifirò Giuseppe, Zonta Mark, Rastrelli Marco, Schenone Francesco, Verrecchia Francesco
Division of Melanoma and Soft Tissue Sarcoma, European Institute of Oncology, Milan, Italy.
Melanoma Res. 2009 Jun;19(3):125-34. doi: 10.1097/CMR.0b013e328329fe95.
The aim of this review was to analyze the difficulties in diagnosing and treating elderly patients with cutaneous melanoma. It focused on the main causes for late diagnosis and relatively poor prognosis in these patients. Early detection of melanoma is vital to reduce mortality in these patients and surgery is often curative. Adequate treatment of elderly patients with melanoma requires knowledge of the clinical features and histopathology of the disease, and the therapeutic options. This review also examined the main surgical procedures for primary melanoma and regional lymph node staging, and the curative and palliative procedures indicated for those elderly patients with advanced disease. It is expected that several molecular genetic factors will soon provide further prognostic information of possible benefit for elderly patients with melanoma.
本综述的目的是分析老年皮肤黑色素瘤患者的诊断和治疗困难。它聚焦于这些患者诊断延迟和预后相对较差的主要原因。黑色素瘤的早期检测对于降低这些患者的死亡率至关重要,手术通常可治愈。对老年黑色素瘤患者进行充分治疗需要了解该疾病的临床特征、组织病理学以及治疗选择。本综述还研究了原发性黑色素瘤的主要手术方法和区域淋巴结分期,以及针对那些患有晚期疾病的老年患者的根治性和姑息性手术。预计若干分子遗传因素很快将为老年黑色素瘤患者提供可能有益的进一步预后信息。