凋亡相关基因ALG-2在各种起源的肿瘤中表达失调，并对癌细胞的生存能力有影响。
The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability.
作者信息
la Cour Jonas M, Høj Berit R, Mollerup Jens, Simon Ronald, Sauter Guido, Berchtold Martin W
机构信息
Copenhagen Biocenter, Department of Molecular Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen N 2200, Denmark.
出版信息
Mol Oncol. 2008 Apr;1(4):431-9. doi: 10.1016/j.molonc.2007.08.002. Epub 2007 Aug 19.
Abstract
The apoptosis linked gene-2 (ALG-2), discovered as a proapoptotic calcium binding protein, has recently been found upregulated in lung cancer tissue indicating that this protein may play a role in the pathology of cancer cells and/or may be a tumor marker. Using immunohistochemistry on tissue microarrays we analysed the expression of ALG-2 in 7371 tumor tissue samples of various origin as well as in 749 normal tissue samples. Most notably, ALG-2 was upregulated in mesenchymal tumors. No correlation was found between ALG-2 staining intensity and survival of patients with lung, breast or colon cancer. siRNA mediated ALG-2 downregulation led to a significant reduction in viability of HeLa cells indicating that ALG-2 may contribute to tumor development and expansion.
摘要
凋亡相关基因2（ALG-2）作为一种促凋亡钙结合蛋白被发现，最近在肺癌组织中被发现上调，这表明该蛋白可能在癌细胞病理过程中发挥作用和/或可能是一种肿瘤标志物。我们使用组织微阵列免疫组化技术分析了7371个不同来源肿瘤组织样本以及749个正常组织样本中ALG-2的表达。最值得注意的是，ALG-2在间充质肿瘤中上调。未发现ALG-2染色强度与肺癌、乳腺癌或结肠癌患者生存率之间存在相关性。小干扰RNA介导的ALG-2下调导致HeLa细胞活力显著降低，表明ALG-2可能有助于肿瘤的发展和扩大。
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