西洛他唑可预防小鼠短暂性局灶性脑缺血诱导的脑损伤中的出血性转化。
Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage.
作者信息
Nonaka Yuko, Tsuruma Kazuhiro, Shimazawa Masamitsu, Yoshimura Shinichi, Iwama Toru, Hara Hideaki
机构信息
Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan.
出版信息
Neurosci Lett. 2009 Mar 13;452(2):156-61. doi: 10.1016/j.neulet.2009.01.039. Epub 2009 Jan 21.
Cilostazol, an antiplatelet drug used to treat intermittent claudication, has been reported to offer neuroprotection and endothelial protection in animals with ischemic brain injury. Here, we evaluated the protection afforded by cilostazol against ischemic brain injury and hemorrhagic transformation. Mice subjected to a 2-h filamental middle cerebral artery (MCA) occlusion were treated with cilostazol (10mg/kg, intraperitoneally just after the occlusion) or with vehicle. Histological outcomes (infarct volume and hemorrhagic transformation) and Evans blue extravasation were assessed after reperfusion. Mean infarct volume, hemorrhagic transformation, and Evans blue extravasation were all significantly reduced in the cilostazol-treated group. Thus, cilostazol protected against ischemic brain injury and hemorrhagic transformation in mice subjected to transient focal cerebral ischemia.
西洛他唑是一种用于治疗间歇性跛行的抗血小板药物，据报道，它能为缺血性脑损伤动物提供神经保护和内皮保护作用。在此，我们评估了西洛他唑对缺血性脑损伤和出血性转化的保护作用。将小鼠进行2小时的大脑中动脉（MCA）丝线闭塞，闭塞后立即腹腔注射西洛他唑（10mg/kg）或注射溶媒。再灌注后评估组织学结果（梗死体积和出血性转化）以及伊文思蓝外渗情况。西洛他唑治疗组的平均梗死体积、出血性转化和伊文思蓝外渗均显著降低。因此，西洛他唑对短暂性局灶性脑缺血小鼠的缺血性脑损伤和出血性转化具有保护作用。
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