Department of Orthopaedics and Traumatology, San Raffaele Scientific Institute, Via Olgettina 60, I-20132, Milan, Italy.
J Orthop Traumatol. 2008 Mar;9(1):5-10. doi: 10.1007/s10195-008-0097-0. Epub 2008 Mar 13.
The humerus is the second most common site of metastatic bone disease involving long bones. Tumors which have a predilection for dissemination to bone are those of breast, prostate, thyroid, lung and kidney. The rationale for surgical treatment of these lesions is to prevent or treat pathological fractures in order to relieve pain and improve function.
Forty patients who had resection of the proximal humerus for metastatic bone disease and reconstruction with a modular prosthesis were retrospectively reviewed.
Mean functional outcome was 73.1% (Enneking score) and better results were achieved when a reverse prosthesis was implanted. Overall survival was 70% at 1 year, 42.5% at 2 years and 20% at 5 years. Local recurrence occurred in 4 patients, each of whom had initially been treated for a pathological fracture.
It is important to follow rational guidelines, like those of Capanna and Mirels, in order to prevent pathological fractures and to give the patient a definitive treatment, as the advances in the management of cancer prolong the survival of these patients. In this series, satisfactory results were obtained, giving the patients an acceptable quality of life.
肱骨是长骨中第二常见的转移性骨病受累部位。易发生骨转移的肿瘤有乳腺、前列腺、甲状腺、肺和肾。这些病变进行手术治疗的基本原理是预防或治疗病理性骨折,以减轻疼痛和改善功能。
回顾性分析了 40 例因转移性骨病而行肱骨近端切除及采用模块化假体重建的患者。
平均功能预后为 73.1%(恩内金评分),使用反置假体的预后更好。1 年生存率为 70%,2 年生存率为 42.5%,5 年生存率为 20%。4 例患者发生局部复发,均为最初因病理性骨折而接受治疗的患者。
遵循合理的指导方针(如卡帕纳和米尔尔斯的指导方针)非常重要,以预防病理性骨折,并为患者提供确定性治疗,因为癌症治疗的进展延长了这些患者的生存时间。在本系列中,获得了满意的结果,使患者的生活质量得到了提高。