硼中子俘获疗法治疗计划系统THORplan准确性的验证。

Verification of the accuracy of BNCT treatment planning system THORplan.

作者信息

Li H S, Liu Y-W H, Lee C Y, Lin T Y, Hsu F Y

机构信息

Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan, ROC.

出版信息

Appl Radiat Isot. 2009 Jul;67(7-8 Suppl):S122-5. doi: 10.1016/j.apradiso.2009.03.029. Epub 2009 Mar 26.

DOI:10.1016/j.apradiso.2009.03.029

PMID:19386507

Abstract

THORplan is a treatment planning system developed at Tsing Hua University, Taiwan, for boron neutron capture therapy (BNCT) purpose. It is recently developed with user-friendly interface using Interactive Data Language. In this article the accuracy of THORplan is verified by comparing results of Snyder phantom calculation with the analytical model results of MCNP. Neutron source from THOR epithermal neutron beam is used as the source for the calculation. The thermal neutron flux calculated by THORplan is very close to the reference results. SERA overestimates thermal neutron flux by 2-5%. NCTPlan underestimates thermal neutron flux by 4-9% in most locations. The total weighted dose calculated by THORplan is accurate to within 3% except at the tissue interface. SERA overestimates the total weighted dose at depth >1.5 cm by 2-5%. NCTPlan underestimates the total weighted dose by approximately 10% at depth >1cm.

摘要

THORplan是台湾清华大学开发的一种用于硼中子俘获疗法（BNCT）的治疗计划系统。它是最近使用交互式数据语言开发的，具有用户友好的界面。在本文中，通过将Snyder体模计算结果与MCNP的分析模型结果进行比较，验证了THORplan的准确性。THOR超热中子束的中子源用作计算源。THORplan计算的热中子通量与参考结果非常接近。SERA高估热中子通量2%-5%。在大多数位置，NCTPlan低估热中子通量4%-9%。除组织界面外，THORplan计算的总加权剂量精确到3%以内。SERA在深度>1.5 cm处高估总加权剂量2%-5%。在深度>1 cm处，NCTPlan低估总加权剂量约10%。