Bosboom J L W, Stoffers D, Stam C J, Berendse H W, Wolters E Ch
Department of Neurology, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
Clin Neurophysiol. 2009 May;120(5):910-5. doi: 10.1016/j.clinph.2009.03.004. Epub 2009 Apr 21.
EEG and MEG studies in Parkinson's disease (PD) related dementia (PDD) have shown a slowing of resting-state, oscillatory activity compared to non demented PD. Aim of the present MEG study was to determine whether treatment with the cholinesterase inhibitor rivastigmine would reverse this slowing of resting-state activity in PDD patients.
In eight PDD patients, whole head MEG was recorded in a resting-state condition before and after treatment with rivastigmine. Relative spectral power was calculated in the delta, theta, alpha, beta and gamma frequency bands in fronto-central, parieto-occipital and temporal regions.
After treatment with rivastigmine, PDD patients demonstrated an increase in relative power in the alpha range in parieto-occipital and temporal regions together with a diffuse increase in beta power. Furthermore, a decrease of delta power in fronto-central and parieto-occipital regions was found.
Treatment with the cholinesterase inhibitor rivastigmine at least partly counteracts the slowing of resting-state brain activity that is known to occur in PD related dementia.
Our observations emphasize the prominent role of degeneration of the cholinergic system in the pathophysiology of dementia in PD. In the future, MEG might contribute to the selection of PD patients who may optimally benefit from cholinergic treatment.
脑电图（EEG）和脑磁图（MEG）研究表明，与非痴呆帕金森病（PD）患者相比，帕金森病相关痴呆（PDD）患者静息状态下的振荡活动减缓。本MEG研究的目的是确定用胆碱酯酶抑制剂卡巴拉汀治疗是否能逆转PDD患者静息状态活动的减缓。
对8例PDD患者在接受卡巴拉汀治疗前后的静息状态下进行全脑MEG记录。计算额中央、顶枕和颞区在δ、θ、α、β和γ频段的相对谱功率。
卡巴拉汀治疗后，PDD患者顶枕和颞区α频段的相对功率增加，同时β功率普遍增加。此外，还发现额中央和顶枕区的δ功率降低。
胆碱酯酶抑制剂卡巴拉汀治疗至少部分抵消了PD相关痴呆中已知的静息状态脑活动减缓。
我们的观察结果强调了胆碱能系统退化在PD痴呆病理生理学中的重要作用。未来，MEG可能有助于选择可能从胆碱能治疗中获得最佳益处的PD患者。
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