Baxendale Ian R, Ley Steven V, Mansfield Andrew C, Smith Christopher D
ITC, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Angew Chem Int Ed Engl. 2009;48(22):4017-21. doi: 10.1002/anie.200900970.
Multistep in flow: The Seyferth-Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three-step oxidation/homologation/copper(I)-catalyzed azide-alkyne cycloaddition sequence without isolation of intermediates (see scheme).
赛费特-吉尔伯特试剂1已应用于流动体系中以快速合成末端炔烃。该体系已进一步应用于从醇2出发，通过三步氧化/同系化/铜（I）催化的叠氮化物-炔烃环加成序列合成三唑3，无需分离中间体（见方案）。
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