Saposnik Gustavo, Black Sandra
Stroke Research Program, South East Toronto Regional Stroke Center, Division of Neurology, Department of Medicine, St. Michael's Hospital, Ont., Canada.
Cerebrovasc Dis. 2009;27(6):537-43. doi: 10.1159/000214216. Epub 2009 Apr 24.
The worldwide growing number of older people represents a new phenomenon. Considering that the prevalence of stroke increases with age and higher life expectancy, the prevalence of stroke will likely rise in the next decade. However, limited information is available about the burden of stroke in individuals over 90.
This is a subgroup analysis from a multicenter cohort study including individuals admitted with an ischemic stroke to a broad range of hospitals across Canada. Patients were identified from the Canadian Hospital Morbidity database (HMDB), which is a national database that contains patient-level sociodemographic, diagnostic and administrative information. Multivariable analysis was performed using logistic regression. Outcomes measures include risk-adjusted stroke fatality, ICU admissions, medical complications, length of hospital stay and discharge disposition.
Among 26,676 patients with ischemic stroke admitted to 606 hospitals, 2,015 (7.6%) were aged 90 years or older. Risk-adjusted fatality at discharge was 6.3% (age <69), 12.5% (age 70-79), 22.0% (age 80-89) and 36.1% (age >or=90) (p < 0.001). Patients aged 90 and over were more likely admitted on weekends (28.1 vs. 24.6; p < 0.001), and less likely to be admitted to the ICU (4.3 vs. 13.0%, p < 0.001) and discharged to their pre-stroke residence (39.9% for those over 90 vs. 57.3% for patients younger than 90, p < 0.001). In the multivariable analysis, nonagenarians and older were 5-8 times more likely to die after adjusting for covariates.
In our study, stroke patients over 90 had higher risk-adjusted mortality, longer hospitalization, and were less likely to be discharged to their original place of residence. In view of these findings, strategies need to be implemented to facilitate equal access to specialized stroke care for the elderly.
全球老年人口数量不断增加,这是一个新现象。鉴于中风患病率随年龄增长和预期寿命延长而上升,未来十年中风患病率可能会上升。然而,关于90岁以上人群中风负担的信息有限。
这是一项多中心队列研究的亚组分析,研究对象为加拿大各地多家医院收治的缺血性中风患者。患者从加拿大医院发病率数据库(HMDB)中识别,该数据库是一个包含患者层面社会人口统计学、诊断和管理信息的国家数据库。使用逻辑回归进行多变量分析。结局指标包括风险调整后的中风死亡率、重症监护病房(ICU)入院率、医疗并发症、住院时间和出院处置情况。
在606家医院收治的26676例缺血性中风患者中,2015例(7.6%)年龄在90岁及以上。出院时风险调整后的死亡率分别为6.3%(年龄<69岁)、12.5%(年龄70 - 79岁)、22.0%(年龄80 - 89岁)和36.1%(年龄≥90岁)(p<0.001)。90岁及以上患者周末入院的可能性更大(28.1%对24.6%;p<0.001),入住ICU的可能性更小(4.3%对13.0%,p<0.