在土耳其伊斯坦布尔的两家大学医院中，替加环素与其他抗菌药物对肺炎链球菌、流感嗜血杆菌和卡他莫拉菌的体外活性比较。

Comparison of in vitro activities of tigecycline with other antimicrobial agents against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in two university hospitals in Istanbul, Turkey.

作者信息

Gonullu Nevriye, Catal Fadimana, Kucukbasmaci Omer, Ozdemir Sinem, Torun Muzeyyen Mamal, Berkiten Rahmiye

机构信息

Department of Microbiology and Clinical Microbiology, Cerrahpasa Faculty of Medicine, University of Istanbul, Istanbul, Turkey.

出版信息

Chemotherapy. 2009;55(3):161-7. doi: 10.1159/000214144. Epub 2009 Apr 22.

DOI:10.1159/000214144

PMID:19390189

Abstract

BACKGROUND

We compared the in vitro activities of tigecycline with those of other agents against 97 Streptococcus pneumoniae, 140 Haemophilus influenzae and 54 Moraxella catarrhalis strains isolated in two large university hospitals in Istanbul.

METHODS

For analysis, the agar dilution method was used.

RESULTS

For S. pneumoniae isolates, 32% were not susceptible to penicillin (28.9% intermediate and 3.1% resistant). Cefotaxime, telithromycin, moxifloxacin and linezolid were fully active. Tigecycline had a 90% minimum inhibitory concentration (MIC(90)) of 0.12 microg/ml. For H. influenzae, 8.57% were not susceptible to ampicillin, among which 8 possessed beta-lactamase (5.7%). Four (2.87%) H. influenzae isolates with beta-lactamase-negative and ampicillin-resistant phenotype were found. All isolates were susceptible to ceftriaxone, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin. MIC(90) for tigecycline was 0.5 microg/ml. Of 54 M. catarrhalis isolates, 88.9% possessed beta-lactamase. Tigecycline and fluoroquinolones were highly active (MIC(90) < or =0.12 microg/ml).

CONCLUSIONS

Linezolid, telithromycin, newer fluoroquinolones and tigecycline all have excellent in vitro activities against the 3 respiratory pathogens.

摘要

背景

我们比较了替加环素与其他药物对在伊斯坦布尔的两家大型大学医院分离出的97株肺炎链球菌、140株流感嗜血杆菌和54株卡他莫拉菌的体外活性。

方法

采用琼脂稀释法进行分析。

结果

对于肺炎链球菌分离株，32%对青霉素不敏感（28.9%中介，3.1%耐药）。头孢噻肟、泰利霉素、莫西沙星和利奈唑胺完全有活性。替加环素的90%最低抑菌浓度（MIC90）为0.12μg/ml。对于流感嗜血杆菌，8.57%对氨苄西林不敏感，其中8株产β-内酰胺酶（5.7%）。发现4株（2.87%）流感嗜血杆菌分离株具有β-内酰胺酶阴性且氨苄西林耐药表型。所有分离株对头孢曲松、阿奇霉素、环丙沙星、左氧氟沙星和莫西沙星敏感。替加环素的MIC90为0.5μg/ml。在54株卡他莫拉菌分离株中，88.9%产β-内酰胺酶。替加环素和氟喹诺酮类药物活性很高（MIC90≤0.12μg/ml）。