抗生素浸渍的脑室-腹腔分流管在感染高风险患者中的应用。
Antibiotic-impregnated ventriculo-peritoneal shunts in patients at high risk of infection.
机构信息
Institute of Neurosurgery, Catholic University School of Medicine, l.go A. Gemelli, 8, 00168 Rome, Italy.
出版信息
Acta Neurochir (Wien). 2009 Oct;151(10):1259-63. doi: 10.1007/s00701-009-0317-2. Epub 2009 Apr 24.
PURPOSE
To determine the efficacy of antibiotic impregnated shunts (AIS) in reducing shunt infections in a population at high risk of shunt infection.
METHODS
From October 2005 to October 2007, patients at high risk of infection (severely disabled, not able to take care of themselves, frequent nosocomial infections) were selected from the 198 adults who underwent shunt placement.
RESULTS
Eighteen adults were identified (mean age 61.8 years). Six patients had AISs, and 12 patients had non-AISs. Groups did not differ in age, sex, type of hydrocephalus or hospital stay before shunting. Shunt infection occurred in 7/12 cases of the non-AIS group (58.3%) versus no infections in the AIS group. In six of seven cases, infection occurred within the first 6 months after surgery. A prevalence of S. epidermidis was detected.
CONCLUSIONS
We believe that in these patients AIS could be effective. Larger, prospective studies are needed in order to definitely address this issue.
目的
确定抗生素浸渍分流器（AIS）在降低高感染风险人群分流感染中的效果。
方法
从 2005 年 10 月至 2007 年 10 月，从 198 名接受分流术的成年人中选择了感染风险高的患者（严重残疾、无法自理、经常发生医院感染）。
结果
共确定了 18 名成年人（平均年龄 61.8 岁）。6 名患者使用 AIS，12 名患者使用非 AIS。两组在年龄、性别、脑积水类型或分流术前住院时间方面无差异。非 AIS 组的 12 例中有 7 例（58.3%）发生分流感染，而 AIS 组无感染。在 7 例感染中，有 6 例发生在手术后 6 个月内。检测到表皮葡萄球菌的流行。
结论
我们认为在这些患者中，AIS 可能是有效的。需要更大规模的前瞻性研究来明确解决这个问题。
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