Yi Hong L, Yin Shan K, Zhang Yu J, Chen Bin, Lu Wen Y, Sun Xiao Q, Cao Zhen Y, Wu Hong M, Guan Jian
Department of Otorhinolaryngology, Affiliated Shanghai Sixth People's Hospital of Shanghai Jiao Tong University, Shanghai, China.
Otolaryngol Head Neck Surg. 2009 May;140(5):640-5. doi: 10.1016/j.otohns.2009.02.002. Epub 2009 Mar 17.
To explore the feasibility, outcomes, and factors affecting the outcome of Z-palatopharyngoplasty (ZP3) in the treatment of severe obstructive sleep apnea/hypopnea syndrome (OSAHS).
Case series with chart review.
ZP3 was performed on 34 Friedman stage II/III OSAHS patients with a posterior airway space (PAS) > or = 11 mm. Postoperative follow-up was at least 6 months, and the differences between responders and nonresponders were analyzed.
On the basis of success criteria, defined as an apnea-hypopnea index < 20 and a decrease > 50 percent, the success rate was 64.7 percent. The lowest oxygen saturation (LSaO(2)), percentage of time with an oxyhemoglobin saturation below 90 percent (CT(90)), mandibular plane angle (MPA), mandibular body length, position of the tongue, and Friedman clinical stage differed significantly between responders and nonresponders. The logistic regression analysis showed that MPA and Friedman stage were the key predictors of ZP3 surgical success. The best cutoff points for LSaO(2), CT(90), and MPA were 72 percent, 22.80 percent, and 29.40 degrees , respectively.
Factors affecting the outcome of ZP3 included LSaO(2), CT(90), MPA, mandibular body length, position of the tongue, and Friedman clinical stage. Of these, the MPA and Friedman clinical stage were most influential.
探讨Z型腭咽成形术(ZP3)治疗重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的可行性、疗效及影响疗效的因素。
病例系列研究并进行图表回顾。
对34例Friedman II/III期、后气道间隙(PAS)≥11 mm的OSAHS患者实施ZP3手术。术后随访至少6个月,分析手术有效者和无效者之间的差异。
根据呼吸暂停低通气指数<20且下降幅度>50%的成功标准,成功率为64.7%。手术有效者和无效者之间的最低血氧饱和度(LSaO₂)、氧合血红蛋白饱和度低于90%的时间百分比(CT₉₀)、下颌平面角(MPA)、下颌体长、舌位置及Friedman临床分期存在显著差异。Logistic回归分析显示,MPA和Friedman分期是ZP3手术成功的关键预测因素。LSaO₂、CT₉₀和MPA的最佳截断点分别为72%、22.80%和29.40°。
影响ZP3疗效的因素包括LSaO₂、CT₉₀、MPA、下颌体长、舌位置及Friedman临床分期。其中,MPA和Friedman临床分期影响最大。