淋巴细胞性漏斗神经垂体炎：儿童复发性视神经病变的一种罕见病因。

Lymphocytic infundibulo-neurohypophysitis: An unusual cause of recurrent optic neuropathy in a child.

作者信息

Al-Mujaini Abdullah, Ganesh Anuradha, Al-Zuhaibi Sana, Al-Dhuhli Humoud, Al-Mashani Ali, Al-Kindi Hunaina, Al-Memari Ali, Al-Futaisi Amna, Al-Asmi Abdullah

机构信息

Department of Ophthalmology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.

出版信息

J AAPOS. 2009 Apr;13(2):207-9. doi: 10.1016/j.jaapos.2008.11.003.

DOI:10.1016/j.jaapos.2008.11.003

PMID:19393522

Abstract

Lymphocytic infundibulo-neurohypophysitis (LINH), a rare autoimmune disease, is distinct from lymphocytic hypophysitis and is characterized by lymphocytic and plasma cell infiltration of the posterior lobe of the pituitary and the pituitary stalk.(1) We report the case of a young boy who presented with recurrent, steroid-responsive optic nerve dysfunction and diabetes insipidus. T1-weighted magnetic resonance imaging scans of the brain showed an isointense soft tissue mass within the sella turcica and a thickened pituitary stalk. Tissue specimen resected at transsphenoidal surgery revealed chronic inflammation with infiltration of lymphocytes and no granulomatosis or necrosis, establishing the diagnosis of LINH.(2) This is the first report of optic neuropathy in association with LINH in a child.

摘要

淋巴细胞性漏斗神经垂体炎（LINH）是一种罕见的自身免疫性疾病，与淋巴细胞性垂体炎不同，其特征是垂体后叶和垂体柄有淋巴细胞和浆细胞浸润。（1）我们报告了一名年轻男孩的病例，他出现复发性、对类固醇有反应的视神经功能障碍和尿崩症。脑部的T1加权磁共振成像扫描显示蝶鞍内有等密度软组织肿块和垂体柄增粗。经蝶窦手术切除的组织标本显示有淋巴细胞浸润的慢性炎症，无肉芽肿形成或坏死，确诊为LINH。（2）这是首例儿童LINH伴发视神经病变的报告。