Hanly Patrick
Sleep Centre, Foothills Medical Centre, University of Calgary, Alberta, Canada.
Adv Chronic Kidney Dis. 2009 May;16(3):179-88. doi: 10.1053/j.ackd.2009.02.004.
Sleep disorders, such as restless legs, periodic limb movements and sleep apnea, and sleep complaints such as insomnia and daytime sleepiness, are very common in end-stage renal disease patients despite treatment with 3-times-a-week conventional hemodialysis. If left untreated, they are likely to impair quality of life and may alter cardiovascular outcomes in this patient population. Home dialysis has the potential to improve sleep disorders by offering more effective dialysis than conventional modalities. Although there has been little direct comparison between the impact of home dialysis and conventional dialysis on sleep disorders, there is evidence that both nocturnal peritoneal dialysis and nocturnal hemodialysis improve sleep apnea. The impact of home dialysis on other sleep disorders and sleep complaints is less impressive, but the data, thus far, have been limited. Further research is required to evaluate the impact of home dialysis on all sleep disorders and sleep complaints in this patient population and to determine whether this improves quality of life and cardiovascular morbidity and mortality.
睡眠障碍,如不宁腿综合征、周期性肢体运动和睡眠呼吸暂停,以及失眠和日间嗜睡等睡眠问题,在接受每周三次常规血液透析治疗的终末期肾病患者中非常常见。如果不进行治疗,这些睡眠障碍可能会损害患者的生活质量,并可能改变该患者群体的心血管结局。家庭透析有可能通过提供比传统方式更有效的透析来改善睡眠障碍。尽管家庭透析和传统透析对睡眠障碍的影响鲜有直接比较,但有证据表明夜间腹膜透析和夜间血液透析均可改善睡眠呼吸暂停。家庭透析对其他睡眠障碍和睡眠问题的影响不太显著,但目前数据有限。需要进一步研究来评估家庭透析对该患者群体所有睡眠障碍和睡眠问题的影响,并确定这是否能改善生活质量以及心血管发病率和死亡率。