吗啡依赖和对照的感染SIV/SHIV猕猴大脑中SIV包膜V1V2区域的分析
Analysis of the V1V2 region of the SIV envelope in the brains of morphine-dependent and control SIV/SHIV-infected macaques.
作者信息
Rivera-Amill Vanessa, Noel Richard J, Román Ivelisse Rivera, Flores Yashira García, Buch Shilpa, Kumar Anil
机构信息
Department of Microbiology, Ponce School of Medicine, Ponce, Puerto Rico 00732.
出版信息
AIDS Res Hum Retroviruses. 2009 May;25(5):531-4. doi: 10.1089/aid.2008.0279.
Abstract
Six morphine-dependent and three control macaques were infected with a mixture of SIV/SHIV. Half of the animals in the morphine group developed accelerated disease (rapid progressor) and died within 20 weeks postinfection. The evolution of the envelope gene in the brain of the rapid progressor and morphine-dependent group along with that in the control group was assessed. Six to 10 clones from the brain of each macaque were sequenced and were compared against each other as well as against a challenge virus. Analysis of the sequences revealed that the diversity and divergence of the clones were higher in the control group as compared to the morphine-dependent macaques, although this difference was not statistically significant.
摘要
六只吗啡依赖的猕猴和三只对照猕猴感染了SIV/SHIV混合物。吗啡组中有一半动物病情加速发展（快速进展者），并在感染后20周内死亡。评估了快速进展者和吗啡依赖组猕猴大脑中包膜基因的进化情况以及对照组的情况。对每只猕猴大脑中的6至10个克隆进行测序，并将它们相互比较，同时与攻击病毒进行比较。序列分析显示，与吗啡依赖的猕猴相比，对照组克隆的多样性和差异更高，尽管这种差异没有统计学意义。
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