UAP56——在前体mRNA剪接和核输出中扮演着具有惊人多样作用的关键角色。

UAP56- a key player with surprisingly diverse roles in pre-mRNA splicing and nuclear export.

作者信息

Shen Haihong

机构信息

Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, Korea.

出版信息

BMB Rep. 2009 Apr 30;42(4):185-8. doi: 10.5483/bmbrep.2009.42.4.185.

DOI:10.5483/bmbrep.2009.42.4.185

PMID:19403039

Abstract

Transcripts contain introns that are usually removed from premessenger RNA (MRNA) in the process of pre-mRNA splicing. After splicing, the mature RNA is exported from the nucleus to the cytoplasm. The splicing and export processes are coupled. UAP56 protein, which is ubiquitously present in organisms from yeasts to humans, is a DExD/H-box family RNA helicase that is an essential splicing factor with various functions in the prespliceosome assembly and mature spliceosome assembly. Collective evidence indicates that UAP56 has an essential role in mRNA nuclear export. This mini-review summarizes recent evidence for the role of UAP56 in pre-mRNA splicing and nuclear export.

摘要

转录本包含内含子，这些内含子通常在信使前体RNA（mRNA）的剪接过程中从前体mRNA中去除。剪接后，成熟的RNA从细胞核输出到细胞质。剪接和输出过程是相互关联的。UAP56蛋白在从酵母到人类的生物体中普遍存在，它是一种DExD/H盒家族RNA解旋酶，是一种必需的剪接因子，在剪接体前体组装和成熟剪接体组装中具有多种功能。综合证据表明，UAP56在mRNA核输出中起重要作用。这篇小型综述总结了UAP56在信使前体RNA剪接和核输出中作用的最新证据。