de la Calzada Dolores García, García Laura Oroz, Remírez Jesús M, Lázaro Ana, Cajal Mercedes Domínguez
Cardiology Section, Univ. Children's Hosp. Miguel Servet, Zaragoza, Spain.
Pediatr Endocrinol Rev. 2009 Feb;6 Suppl 3:343-9.
Many children are born small for gestational age (SGA), due to intrauterine growth retardation (IUGR) and in recent years we have witnessed an increase in the prevalence of this problem. In our region, Aragon, 5% of children (between 550-600 per year) are born SGA, which represents a serious public health problem. Some studies have suggested that these patients have a higher risk of suffering from high blood pressure (HBP), dyslipidemia, obesity, insulin resistant diabetes and atherosclerosis in adulthood. Nevertheless other publications do not support this hypothesis, so given the lack of consensus on the potential risks of this situation, we believed it would be interesting to study, at an early stage of life, whether a sample of children born SGA would present greater cardiovascular risk factors than children born with an adequate weight for gestational age (AGA).
许多儿童因宫内生长迟缓(IUGR)而出生时小于胎龄(SGA),近年来我们目睹了这一问题患病率的上升。在我们所在的阿拉贡地区,5%的儿童(每年550 - 600名)出生时小于胎龄,这是一个严重的公共卫生问题。一些研究表明,这些患者成年后患高血压(HBP)、血脂异常、肥胖、胰岛素抵抗性糖尿病和动脉粥样硬化的风险更高。然而,其他出版物并不支持这一假设,所以鉴于对这种情况潜在风险缺乏共识,我们认为在生命早期研究小于胎龄出生的儿童样本是否会比出生时体重与胎龄相称(AGA)的儿童呈现出更大的心血管危险因素会很有意思。