[母亲患有特发性血小板减少性紫癜的胎儿及新生儿血小板计数的产前评估]

[Prenatal evaluation of the platelet counts in the fetuses and the neonates of the mothers complicated with idiopathic thrombocytopenic purpura].

作者信息

Masuhiro K, Mitsuda N, Iwata M, Hosono T, Iwata I, Takagi T, Tanizawa O, Kurata Y

机构信息

Department of Obstetrics and Gynecology, Osaka University Medical School.

出版信息

Nihon Sanka Fujinka Gakkai Zasshi. 1991 Nov;43(11):1521-6.

PMID:1940548

Abstract

We investigated 25 pregnancies with ITP. The results were as follows. 1. The platelet counts of the maternal blood just before delivery were not correlated with those of the cord blood. 2. It was suggested that the maternal PAIgG value just before delivery could foretell the onset of neonatal thrombocytopenic purpura. 3. The platelet counts in fetal scalp blood were correlated with those of the cord blood, but falsely lower platelet counts were found in the fetal scalp samples. 4. We saw 5 cases of percutaneous umbilical blood sampling (PUBS) in pregnancies with ITP. PUBS was found to be a useful and safe method. The indications for PUBS and fetal platelet transfusion in pregnancy with ITP are discussed.

摘要

我们对25例患有免疫性血小板减少症（ITP）的孕妇进行了研究。结果如下：1. 临产前母血的血小板计数与脐血的血小板计数无相关性。2. 提示临产前母体血小板相关免疫球蛋白G（PAIgG）值可预测新生儿血小板减少性紫癜的发病。3. 胎儿头皮血的血小板计数与脐血的血小板计数相关，但在胎儿头皮样本中发现血小板计数有假性降低。4. 我们在患有ITP的孕妇中观察到5例经皮脐血采样（PUBS）。发现PUBS是一种有用且安全的方法。文中讨论了ITP孕妇进行PUBS和胎儿血小板输血的指征。