Norozi Kambiz, Binder Lutz, Brack Christoph, Potthoff Ludger, Hess Georg, Wessel Armin
Department of Paediatric Cardiology and Intensive Care Medicine, Medical School Hannover, Hannover, Germany.
Pediatr Int. 2009 Apr;51(2):283-8. doi: 10.1111/j.1442-200X.2008.02710.x.
Little is known about the acute effects of i.v. luteinizing hormone-releasing hormone (LHRH) on the heart function, therefore the aim of the present study was to measure N-terminal pro-brain natriuretic peptide (N-BNP) in children, who underwent a diagnostic work up for short stature or delayed puberty.
N-BNP was measured in 52 children before and after administration of LHRH. Serum N-BNP obtained from 255 healthy children and adolescents (aged birth-18.3 years) served as a reference.
There was no significant difference between baseline N-BNP of children who underwent the LHRH diagnostic test and their healthy peers. There was no significant serum N-BNP level change before or after administration of LHRH (59 +/- 36 pg/mL vs 58 +/- 34 pg/mL). N-BNP fell from 399 +/- 425 pg/mL in newborns and reached 44 +/- 36 pg/mL in children aged 12-18 years.
Short stature or delayed puberty had no effect on heart function determined by serum N-BNP; i.v. LHRH does not acutely influence the level of serum N-BNP.
关于静脉注射促黄体生成素释放激素（LHRH）对心脏功能的急性影响知之甚少，因此本研究的目的是测量因身材矮小或青春期延迟而接受诊断性检查的儿童的N端前脑钠肽（N-BNP）。
在52名儿童注射LHRH前后测量N-BNP。从255名健康儿童和青少年（年龄从出生到18.3岁）获得的血清N-BNP作为对照。
接受LHRH诊断测试的儿童与健康同龄人在基线N-BNP水平上没有显著差异。注射LHRH前后血清N-BNP水平没有显著变化（59±36 pg/mL对58±34 pg/mL）。N-BNP从新生儿的399±425 pg/mL下降到12 - 18岁儿童的44±36 pg/mL。
身材矮小或青春期延迟对血清N-BNP所确定的心脏功能没有影响；静脉注射LHRH不会急性影响血清N-BNP水平。
