Collins William E, Sullivan Joann S, Warren McWilson, Galland G Gale, Williams Allison, Barnwell John W
Division of Parasitic Diseases and Scientific Resources Branch, National Center for Vector-Borne and Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Atlanta, Georgia 30333, USA.
Am J Trop Med Hyg. 2009 May;80(5):739-44.
Macaca mulatta monkeys infected with the Hackeri strain of Plasmodium fieldi had maximum parasite counts ranging from 1,300 to 301,320/microL. In 43 intact animals infected with the ABI strain, the maximum parasite counts ranged from 672 to 57,189/microL (median = 15,100/microL); in 46 splenectomized monkeys, the maximum parasite count ranged from 660 to 350,000/microL (median = 52,245/microL). Transmission through Anopheles dirus mosquitoes was obtained on 11 occasions with pre-patent periods of 9-14 days. Relapses occurred between two and eight times during a 1-year period. P. fieldi has potential for testing prophylactic and radical curative drugs.
感染菲氏疟原虫哈克里株的恒河猴的最高寄生虫计数范围为每微升1300至301320个。在43只感染ABI株的完整动物中,最高寄生虫计数范围为每微升672至57189个(中位数=每微升15100个);在46只脾切除的猴子中,最高寄生虫计数范围为每微升660至350000个(中位数=每微升52245个)。通过大劣按蚊传播11次成功,潜伏期为9至14天。在1年期间复发2至8次。菲氏疟原虫有用于测试预防和根治性药物的潜力。