Choi Raymond, Andres Robert H, Steinberg Gary K, Guzman Raphael
Department of Neurosurgery, Stanford University Medical Center, Stanford, California 94305-5327, USA.
Neurosurg Focus. 2009 May;26(5):E24. doi: 10.3171/2009.3.FOCUS0927.
Increasing evidence in animal models and clinical trials for stroke, hypoxic encephalopathy for children, and traumatic brain injury have shown that mild hypothermia may attenuate ischemic damage and improve neurological outcome. However, it is less clear if mild intraoperative hypothermia during vascular neurosurgical procedures results in improved outcomes for patients. This review examines the scientific evidence behind hypothermia as a treatment and discusses factors that may be important for the use of this adjuvant technique, including cooling temperature, duration of hypothermia, and rate of rewarming.
越来越多针对中风、儿童缺氧性脑病和创伤性脑损伤的动物模型及临床试验证据表明,轻度低温可能减轻缺血性损伤并改善神经功能转归。然而,血管神经外科手术期间的术中轻度低温是否能改善患者预后尚不清楚。本综述探讨了低温作为一种治疗手段背后的科学证据,并讨论了对于使用这种辅助技术可能重要的因素,包括降温温度、低温持续时间和复温速率。