Bardou Olivier, Trinh Nguyen Thu Ngan, Brochiero Emmanuelle
Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM), Hôtel-Dieu, 3840, St-Urbain, Montréal, Québec, H2W 1T8 Canada.
Med Sci (Paris). 2009 Apr;25(4):391-7. doi: 10.1051/medsci/2009254391.
Transcripts of more than 30 different K(+) channels have been detected in the respiratory epithelium lining airways and alveoli. These channels belong to the 3 main classes of K(+) channels, i.e. i) voltage-dependent or calcium-activated, 6 transmembrane segments (TM), ii) 2-pores 4-TM and iii) inward-rectified 2-TM channels. The physiological and functional significance of this high molecular diversity of lung epithelial K(+) channels is not well understood. Surprisingly, relatively few studies are focused on K(+) channel function in lung epithelial physiology. Nevertheless, several studies have shown that KvLQT1, KCa and K(ATP) K(+) channels play a crucial role in ion and fluid transport, contributing to the control of airway and alveolar surface liquid composition and volume. K(+) channels are involved in other key functions, such as O(2) sensing or the capacity of the respiratory epithelia to repair after injury. This mini-review aims to discuss potential functions of lung K(+) channels.
在气道和肺泡的呼吸上皮中已检测到30多种不同钾离子通道的转录本。这些通道属于钾离子通道的3个主要类别，即：i）电压依赖性或钙激活的、6个跨膜片段（TM）的通道；ii）2孔4-TM通道；iii）内向整流2-TM通道。肺上皮钾离子通道这种高分子多样性的生理和功能意义尚未完全明了。令人惊讶的是，相对较少的研究聚焦于肺上皮生理学中钾离子通道的功能。然而，多项研究表明，KvLQT1、KCa和K(ATP)钾离子通道在离子和液体转运中起关键作用，有助于控制气道和肺泡表面液体的成分和体积。钾离子通道还参与其他关键功能，如氧气感知或呼吸上皮损伤后的修复能力。本综述旨在探讨肺钾离子通道的潜在功能。
