Behan W M, Bakheit A M, Behan P O, More I A
University of Glasgow, Department of Pathology, UK.
J Neurol Neurosurg Psychiatry. 1991 Aug;54(8):741-3. doi: 10.1136/jnnp.54.8.741.
A detailed pathological description of the muscle findings in a case of the neuroleptic malignant syndrome (NMS) following ingestion of lysergic acid diethylamide (LSD) is given, including the first ultrastructural analysis. Focal necrosis, oedema, and hypercontraction of fibres with glycogen and lipid depletion, were identified, all of which had resolved completely a year later. The findings are compared with those in malignant hyperthermia. It is suggested that the results support the view that in NMS, the muscle rigidity is due to central mechanisms and, in both this disorder and malignant hyperthermia, it is responsible for the hyperpyrexia and its life-threatening complications.
本文给出了一例服用麦角酸二乙酰胺（LSD）后发生神经阻滞剂恶性综合征（NMS）患者肌肉检查结果的详细病理学描述，包括首次超微结构分析。发现有局灶性坏死、水肿以及纤维的过度收缩，并伴有糖原和脂质耗竭，所有这些在一年后已完全消退。将这些发现与恶性高热的发现进行了比较。结果表明支持以下观点：在NMS中，肌肉强直是由中枢机制引起的，并且在这种疾病和恶性高热中，它都是高热及其危及生命并发症的原因。
