糖尿病患者的鼻眶脑毛霉菌病：突尼斯一种较为常见的病理情况

[Rhino-orbito-cerebral mucormycosis in the diabetic: a better known pathology in Tunisia].

作者信息

Anane S, Kaouech E, Belhadj S, Ammari L, Abdelmalek R, Ben Chaabane T, Ben Lakhal S, Cherif A, Ammamou M, Ben Fadhel K, Kallel K, Chaker E

机构信息

Service de parasitologie-mycologie, CHU la Rabta, Tunis, Tunisie.

出版信息

Ann Biol Clin (Paris). 2009 May-Jun;67(3):325-32. doi: 10.1684/abc.2009.0323.

DOI:10.1684/abc.2009.0323

PMID:19411235

Abstract

This is a retrospective study including 17 patients with rhino-orbito-cerebral mucormycosis diagnosed in a period of 16 years, between 1992 and 2007, in 8 men and 9 women. All patients were diabetic with ketoacidosis diabetes in 8 cases. Necrosis facial and ophthalmic symptoms were the most frequent presenting manifestations. The diagnosis was confirmed by mycological examination, with or without histopathology, identifying Rhizopus oryzae in 12 cases. Treatment consisted in systemic amphotericin B combined with surgical treatment in only 7 cases. The mortality rate was high (65%) due principally to the delay in diagnosis and absence of surgical treatment.

摘要

这是一项回顾性研究，纳入了1992年至2007年16年间确诊的17例鼻眶脑型毛霉菌病患者，其中男性8例，女性9例。所有患者均患有糖尿病，8例为酮症酸中毒糖尿病。面部坏死和眼部症状是最常见的临床表现。通过真菌学检查确诊，无论有无组织病理学检查，12例患者鉴定为米根霉。仅7例患者采用全身两性霉素B联合手术治疗。死亡率较高（65%），主要原因是诊断延误和未进行手术治疗。