Department of Prosthodontics, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7450, USA.
J Oral Rehabil. 2009 Jun;36(6):415-26. doi: 10.1111/j.1365-2842.2009.01954.x. Epub 2009 Apr 28.
The purpose of this analysis was to examine the effect of sensory retraining on sensory function after bilateral sagittal split osteotomy (BSSO). A total of 186 subjects were enrolled in a multi-centre double-blind two parallel group stratified block randomized clinical trial. Subjects were randomized to group immediately after surgery. Threshold measures for contact detection, two-point discrimination and two-point perception were obtained on the chin before and 1, 3 and 6 months and 1 and 2 years after surgery. The ratio of each threshold measure (post-surgery value/pre-surgery value) was calculated to characterize subjects' impairment. A general linear mixed model was fit for the impairment to examine the effect of the sensory retraining before and after adjusting for demographic, surgical and psychological factors. On average, two-point perception was less impaired in subjects who were retrained than in those who were not retrained (P = 0.04). Significant recovery continued up to 6 months after surgery for contact detection and two-point perception and up to 24 months for two-point discrimination. Older subjects experienced more impairment in two-point discrimination than younger subjects (P = 0.009). Subjects who received maxillary surgery in addition to mandibular surgery experienced more impairment on the chin in both two-point discrimination (P = 0.0003) and perception (P = 0.0013) than subjects who received mandibular surgery only. Psychological factors did not explain additional variability in subjects' impairment post-surgery. These finding indicate that a simple non-invasive exercise programme initiated shortly after orthognathic surgery can alter the way patients experience or respond to tactile stimulation long after the exercise regimen has stopped.
本分析旨在研究双侧矢状劈开截骨术(BSSO)后感觉再训练对感觉功能的影响。共有 186 名受试者参加了一项多中心、双盲、两平行组分层随机临床试验。受试者在手术后立即随机分组。在手术前、手术后 1、3、6 个月和 1、2 年内,分别在颏部获得接触检测、两点辨别和两点感知的阈值测量。计算每个阈值测量值(术后值/术前值)的比值来描述受试者的损伤程度。采用一般线性混合模型对损伤进行拟合,以检查在调整人口统计学、手术和心理因素之前和之后感觉再训练的效果。平均而言,与未接受再训练的受试者相比,接受再训练的受试者的两点感知受损程度较低(P = 0.04)。接触检测和两点感知的恢复持续到术后 6 个月,两点辨别术的恢复持续到术后 24 个月。与年轻受试者相比,年龄较大的受试者在两点辨别术方面的损伤更为严重(P = 0.009)。除下颌手术外还接受上颌手术的受试者,在两点辨别术(P = 0.0003)和感知(P = 0.0013)方面,颏部的损伤比仅接受下颌手术的受试者更为严重。心理因素并不能解释术后受试者损伤的额外变异性。这些发现表明,在正颌手术后不久启动的简单非侵入性运动方案,可以改变患者在运动方案停止后很长时间对触觉刺激的体验或反应方式。