自闭症中的自身免疫
Autoimmunity in autism.
作者信息
Enstrom Amanda M, Van de Water Judy A, Ashwood Paul
机构信息
University of California at Davis, Department of Medical Microbiology and Immunology/UC Davis MIND Institute, 2805 50th Street, Sacramento, CA 95817, USA.
出版信息
Curr Opin Investig Drugs. 2009 May;10(5):463-73.
Abstract
Autism spectrum disorders is a heterogenous group of neurodevelopmental disorders, the etiology or etiologies of which remain unknown. Increasing evidence of autoimmune phenomena in individuals with autism could represent the presence of altered or inappropriate immune responses in this disorder, and this immune system dysfunction may represent novel targets for treatment. Furthermore, in recent studies, antibodies directed against the fetal brain have been detected in some mothers of children with autism; these antibodies have the ability to alter behavioral outcomes in the offspring of animal models. A better understanding of the involvement of the immune response in early brain development, with respect to autism, may have important therapeutic implications.
摘要
自闭症谱系障碍是一组异质性的神经发育障碍，其病因仍不清楚。越来越多的证据表明自闭症患者存在自身免疫现象，这可能意味着该疾病中存在改变或不适当的免疫反应，而这种免疫系统功能障碍可能是新的治疗靶点。此外，在最近的研究中，在一些自闭症儿童的母亲体内检测到了针对胎儿大脑的抗体；这些抗体能够改变动物模型后代的行为结果。更好地理解免疫反应在自闭症早期大脑发育中的作用，可能具有重要的治疗意义。
相似文献
1
Autoimmunity in autism.
Curr Opin Investig Drugs. 2009 May;10(5):463-73.
2
Prevalence of serum antibodies to caudate nucleus in autistic children.
Neurosci Lett. 2004 Jan 23;355(1-2):53-6. doi: 10.1016/j.neulet.2003.10.026.
3
Immunity, neuroglia and neuroinflammation in autism.
Int Rev Psychiatry. 2005 Dec;17(6):485-95. doi: 10.1080/02646830500381930.
4
Immune dysfunction in autism: a pathway to treatment.
Neurotherapeutics. 2010 Jul;7(3):283-92. doi: 10.1016/j.nurt.2010.05.003.
5
Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A.
J Neuroimmunol. 2002 Aug;129(1-2):168-77. doi: 10.1016/s0165-5728(02)00180-7.
6
Immunological and autoimmune considerations of Autism Spectrum Disorders.
J Autoimmun. 2013 Aug;44:1-7. doi: 10.1016/j.jaut.2013.05.005. Epub 2013 Jul 15.
7
Phenotypic expression of autoimmune autistic disorder (AAD): a major subset of autism.
Ann Clin Psychiatry. 2009 Jul-Sep;21(3):148-61.
8
Is autism an autoimmune disease?
Autoimmun Rev. 2004 Nov;3(7-8):557-62. doi: 10.1016/j.autrev.2004.07.036.
9
Serum antinucleosome-specific antibody as a marker of autoimmunity in children with autism.
J Neuroinflammation. 2014 Apr 3;11:69. doi: 10.1186/1742-2094-11-69.
10
Immunological findings in autism.
Int Rev Neurobiol. 2005;71:317-41. doi: 10.1016/s0074-7742(05)71013-8.
引用本文的文献
1
Outcomes of autologous bone marrow mononuclear cell administration combined with educational intervention in the treatment of autism spectrum disorder: a randomized, open-label, controlled phase II clinical trial.
Stem Cell Res Ther. 2025 May 30;16(1):268. doi: 10.1186/s13287-025-04404-4.
2
Blood biomarker discovery for autism spectrum disorder: A proteomic analysis.
PLoS One. 2024 Dec 19;19(12):e0302951. doi: 10.1371/journal.pone.0302951. eCollection 2024.
3
Neurodevelopment of Autism: Critical Periods, Stress and Nutrition.
Cells. 2024 Nov 28;13(23):1968. doi: 10.3390/cells13231968.
4
The Role of Dietary Peptides Gluten and Casein in the Development of Autism Spectrum Disorder: Biochemical Perspectives.
Mol Neurobiol. 2024 Oct;61(10):8144-8155. doi: 10.1007/s12035-024-04099-3. Epub 2024 Mar 12.
5
The Exposure to Lead (Pb) Exacerbates Immunological Abnormalities in BTBR T Itpr/J Mice through the Regulation of Signaling Pathways Relevant to T Cells.
Int J Mol Sci. 2023 Nov 11;24(22):16218. doi: 10.3390/ijms242216218.
6
Indicators of HSV1 Infection, ECM-Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia.
J Pers Med. 2023 Sep 18;13(9):1392. doi: 10.3390/jpm13091392.
7
The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases.
Brain Behav Immun. 2023 Aug;112:175-187. doi: 10.1016/j.bbi.2023.06.009. Epub 2023 Jun 8.
8
Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder.
Nat Neurosci. 2023 Apr;26(4):650-663. doi: 10.1038/s41593-023-01259-x. Epub 2023 Mar 9.
9
Exome-wide analysis identify multiple variations in olfactory receptor genes ( and ) associated with autism spectrum disorder in Saudi females.
Front Med (Lausanne). 2023 Feb 1;10:1051039. doi: 10.3389/fmed.2023.1051039. eCollection 2023.
10
Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder.
Turk J Med Sci. 2022 Aug;52(4):1041-1049. doi: 10.55730/1300-0144.5406. Epub 2022 Aug 10.
本文引用的文献
1
The rise in autism and the role of age at diagnosis.
Epidemiology. 2009 Jan;20(1):84-90. doi: 10.1097/EDE.0b013e3181902d15.
2
Elevated immune response in the brain of autistic patients.
J Neuroimmunol. 2009 Feb 15;207(1-2):111-6. doi: 10.1016/j.jneuroim.2008.12.002. Epub 2009 Jan 20.
3
Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17;33(2):303-7. doi: 10.1016/j.pnpbp.2008.12.006. Epub 2008 Dec 24.
4
Serum anti-nuclear antibodies as a marker of autoimmunity in Egyptian autistic children.
Pediatr Neurol. 2009 Feb;40(2):107-12. doi: 10.1016/j.pediatrneurol.2008.10.017.
5
Low natural killer cell cytotoxic activity in autism: the role of glutathione, IL-2 and IL-15.
J Neuroimmunol. 2008 Dec 15;205(1-2):148-54. doi: 10.1016/j.jneuroim.2008.09.005. Epub 2008 Oct 16.
6
Psychopharmacologic interventions for repetitive behaviors in autism spectrum disorders.
Child Adolesc Psychiatr Clin N Am. 2008 Oct;17(4):753-71, viii. doi: 10.1016/j.chc.2008.06.003.
7
Pharmacotherapy of irritability in pervasive developmental disorders.
Child Adolesc Psychiatr Clin N Am. 2008 Oct;17(4):739-52, vii-viii. doi: 10.1016/j.chc.2008.06.002.
8
Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes.
J Neuroimmunol. 2008 Nov 15;204(1-2):149-53. doi: 10.1016/j.jneuroim.2008.07.006.
9
Altered gene expression and function of peripheral blood natural killer cells in children with autism.
Brain Behav Immun. 2009 Jan;23(1):124-33. doi: 10.1016/j.bbi.2008.08.001. Epub 2008 Aug 14.
10
Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders.
Brain Behav Immun. 2009 Jan;23(1):64-74. doi: 10.1016/j.bbi.2008.07.007. Epub 2008 Jul 30.
Zotero 插件