Shi Hai, Wang Wei-Zhong, Yao Li-Bo, Zhang Jian, Yin Qin, Xu Chun-Sheng, Chu Da-Ke, Dong Guang-Long, Zhang Hong-Wei, Li Ji-Peng
Department of Gastrointestinal Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710033, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2009 May;12(3):281-4.
To determine the expression of new candidate tumor suppressor gene N-Myc downstream-regulated gene 2(Ndrg2) in colorectal cancer with different differentiation, and analyze its clinical significance.
Specimens of 50 colorectal cancer patients with different differentiation were collected. Immunohistochemistry and Western blot were used to examine the expression of Ndrg2. Colorectal cancer tissue array in large scale was applied to analyze the expression of Ndrg2 and the statistics analysis was performed referring to the patients information of the array.
Among 50 cases, Ndrg2 expression level of colorectal cancer was significantly lower in 32 cases as compared to adjacent and normal tissue of the same individual, while Ndrg2 expression of adjacent tissue was significantly lower than that of normal tissue. Ndrg2 protein levels increased from poor-differentiated to well-differentiated carcinomas(P=0.005).
The expression of Ndrg2 in different differentiated colorectal cancer tissues show a significant distinction. Ndrg2 may be involved in the regulation of differentiation in colorectal cancer.
检测新的候选抑癌基因N - Myc下游调控基因2（Ndrg2）在不同分化程度结直肠癌中的表达情况，并分析其临床意义。
收集50例不同分化程度的结直肠癌患者标本。采用免疫组织化学和蛋白质印迹法检测Ndrg2的表达。应用大规模结直肠癌组织芯片分析Ndrg2的表达，并参照芯片患者信息进行统计学分析。
50例中，32例结直肠癌组织中Ndrg2表达水平明显低于同一患者的癌旁组织和正常组织，而癌旁组织中Ndrg2表达明显低于正常组织。Ndrg2蛋白水平从低分化癌到高分化癌逐渐升高（P = 0.005）。
Ndrg2在不同分化程度的结直肠癌组织中的表达存在显著差异。Ndrg2可能参与了结直肠癌的分化调控。
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