Department of Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Periodontology, The University of Jordan, Amman, Jordan.
Clin Implant Dent Relat Res. 2010 Sep;12(3):249-53. doi: 10.1111/j.1708-8208.2009.00151.x. Epub 2009 Apr 23.
Cholesterol granuloma (CG) is a foreign-body reaction to the deposition of cholesterol crystals. Its occurrence in the paranasal sinuses is very rare.
This report describes a new case of maxillary sinus CG discovered incidentally during sinus-floor augmentation for dental implant placement in a 60-year-old female patient.
The preoperative clinical and radiological examinations revealed a normal maxillary antrum with no evidence of sinus pathology. After lateral osteotomy, a dark-green, viscous soft tissue mass appeared through the thin mucous membrane inside the sinus. Enucleation and curettage of the sinus contents including the sinus membrane were performed for histopathologic analysis. The augmentation and implant placement procedures were postponed.
Histopathologic analysis showed several fragments of granulation tissue containing diffuse cholesterol clefts surrounded by mixed chronic inflammatory cell infiltrate including plasma cells and lymphocytes. These features were compatible with the diagnosis of CG. The patient was followed up for 3 months after the first procedure, and a second attempt of sinus augmentation and dental implant insertion was then carried out. The inserted dental implants were followed up for 6 months without any complications.
CG of maxillary sinus can be an incidental finding. For this reason, the final diagnosis can only be achieved after examination of the material under the microscope.
胆固醇肉芽肿(CG)是胆固醇晶体沉积引起的异物反应。其在鼻窦中发生非常罕见。
本报告描述了一例新的上颌窦 CG 病例,该病例在 60 岁女性患者行鼻窦底提升以植入牙种植体时偶然发现。
术前临床和影像学检查显示上颌窦正常,无窦病理证据。外侧切开后,通过窦内薄黏膜出现了暗绿色、粘稠的软组织肿块。对包括鼻窦膜在内的窦内容物进行了切除和刮除以进行组织病理学分析。延期进行了提升和种植体植入手术。
组织病理学分析显示,有几个肉芽组织碎片,其中包含弥漫性胆固醇裂隙,周围有浆细胞和淋巴细胞等混合慢性炎症细胞浸润。这些特征与 CG 的诊断相符。首次手术后,对患者进行了 3 个月的随访,随后进行了第二次鼻窦提升和牙种植体植入尝试。插入的牙种植体随访 6 个月无任何并发症。
上颌窦 CG 可能是偶然发现。因此,只有在显微镜下检查材料后才能做出最终诊断。