游离前列腺特异抗原与总前列腺特异抗原的比值可提高十二针穿刺活检中前列腺癌的检出率。

Free PSA/total PSA ratio increases the detection rate of prostate cancer in twelve-core biopsy.

作者信息

Yokomizo Yumiko, Miyoshi Yasuhide, Nakaigawa Noboru, Makiyama Kazuhide, Ogawa Takehiko, Yao Masahiro, Kubota Yoshinobu, Uemura Hiroji

机构信息

Department of Urology, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan.

出版信息

Urol Int. 2009;82(3):280-5. doi: 10.1159/000209358. Epub 2009 May 11.

DOI:10.1159/000209358

PMID:19440014

Abstract

BACKGROUND

In the present study, we compared 12- with 8-core biopsy in patients with prostate-specific antigen (PSA) levels of 4.0-20.0 ng/ml. We also examined whether the free/total (F/T) PSA ratio is useful for cancer detection in 12-core biopsy.

METHODS

A total of 419 men with PSA level between 4.0 and 20.0 ng/ml underwent transrectal ultrasound-guided transperineal needle biopsies of the prostate. Of these men, 235 underwent 8-core biopsy and 184 underwent 12-core biopsy. We compared the cancer detection rate between the 8- and 12-core biopsy groups by analyzing the PSA value, and especially the F/T PSA ratio.

RESULTS

The cancer detection rate in the 12-core group (35.9%) was significantly higher than in the 8-core group (23.8%). In cases of PSA level of 4.0-20.0 ng/ml with F/T PSA ratio less than 0.11, the cancer detection rate was 53.1% in the 12-core biopsy group. Performing 12-core biopsy resulted in a marked difference of cancer detection rate between men with F/T PSA ratio less than 0.11 and those with more than 0.12 in gray zone PSA (48.2% and 17.5%, respectively).

CONCLUSIONS

Twelve-core biopsy can achieve a higher detection rate of prostate cancer than 8-core biopsy using F/T PSA ratio.

摘要

背景

在本研究中，我们比较了前列腺特异性抗原（PSA）水平为4.0 - 20.0 ng/ml的患者进行12针活检与8针活检的情况。我们还研究了游离/总（F/T）PSA比值在12针活检中对癌症检测是否有用。

方法

共有419名PSA水平在4.0至20.0 ng/ml之间的男性接受了经直肠超声引导下的经会阴前列腺穿刺活检。其中，235名男性接受了8针活检，184名男性接受了12针活检。我们通过分析PSA值，特别是F/T PSA比值，比较了8针活检组和12针活检组之间的癌症检出率。

结果

12针活检组的癌症检出率（35.9%）显著高于8针活检组（23.8%）。在PSA水平为4.0 - 20.0 ng/ml且F/T PSA比值小于0.11的病例中，12针活检组的癌症检出率为53.1%。在灰色区域PSA（48.2%和17.5%）中，进行12针活检导致F/T PSA比值小于0.11的男性与大于0.12的男性之间的癌症检出率存在显著差异。