用于治疗神经炎症的成体神经干细胞。圣拉斐尔·德尔蒙特·塔博基金会：WO2007015173。
Adult neural stem cells for the treatment of neuroinflammation. Fondazione Centro San Raffaele del Monte Tabor: WO2007015173.
作者信息
Taupin Philippe
机构信息
Dublin City University, School of Biotechnology, Glasnevin, Dublin 9, Ireland.
出版信息
Expert Opin Ther Pat. 2009 Mar;19(3):373-6. doi: 10.1517/13543770802681649.
BACKGROUND
The application is in the field of stem cells and their therapeutic application for the treatment of inflammation.
OBJECTIVE
It aims at characterizing the potential of adult-derived neural progenitor and stem cells for the treatment of inflammation of the central nervous system (CNS).
METHODS
Neural progenitor and stem cells were isolated and expanded from the subventricular zone (SVZ) of adult mice (aNSCs). They were administered intravenously in an animal model of multiple sclerosis (MS).
RESULTS
Mice transplanted either at the disease onset or at the onset of the first relapse show clinical signs of improvements. Adult NSCs exert their therapeutical activity by reducing neuroinflammation.
CONCLUSION
The application claims the use of aNSCs and multipotent somatic stem cells for the treatment of inflammation, associated with neurological diseases, disorders and injuries particularly, and for inducing tolerance to the immune central and/or peripheral system.
背景
本应用处于干细胞及其治疗炎症的治疗应用领域。
目的
旨在表征成年来源的神经祖细胞和干细胞治疗中枢神经系统（CNS）炎症的潜力。
方法
从成年小鼠的脑室下区（SVZ）分离并扩增神经祖细胞和干细胞（aNSCs）。将它们静脉注射到多发性硬化症（MS）动物模型中。
结果
在疾病发作时或首次复发发作时移植的小鼠显示出临床改善迹象。成年神经干细胞通过减轻神经炎症发挥其治疗活性。
结论
本应用要求使用成年神经干细胞和多能体干细胞治疗炎症，特别是与神经疾病、紊乱和损伤相关的炎症，并诱导对免疫中枢和/或外周系统的耐受性。
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