DeSoto M Catherine
Department of Psychology, University of Northern Iowa, Baker Hall, Cedar Falls, IA 50614-0505, United States.
Neurotoxicology. 2009 May;30(3):331-7. doi: 10.1016/j.neuro.2009.03.003. Epub 2009 Mar 21.
Much professional awareness regarding environmental triggers for ASD has been narrowly focused on a single possible exposure pathway (vaccines). Meanwhile, empirical support for environmental toxins as a broad class has been quietly accumulating. Recent research has shown that persons with ASD have comparatively higher levels of various toxins and are more likely to have reduced detoxifying ability, and, that rates of ASD may be higher in areas with greater pollution. This report documents that within the state with the highest rate of ASD, the rate is higher for schools near EPA Superfund sites, t (332)=3.84, p=.0001. The reasons for the rise in diagnoses likely involve genetically predisposed individuals being exposed to various environmental triggers at higher rates than in past generations.
许多关于自闭症谱系障碍(ASD)环境触发因素的专业认知都狭隘地集中在单一可能的暴露途径(疫苗)上。与此同时,关于环境毒素这一广泛类别作为ASD触发因素的实证支持一直在悄然积累。最近的研究表明,患有ASD的人各种毒素水平相对较高,解毒能力更有可能降低,而且,在污染更严重的地区,ASD的发病率可能更高。本报告记录了在ASD发病率最高的州内,靠近美国环境保护局超级基金场地的学校发病率更高,t(332)=3.84,p = .0001。诊断增加的原因可能涉及具有遗传易感性的个体比过去几代人以更高的频率接触各种环境触发因素。