Broom Reuben J, Tang Patricia A, Simmons Christine, Bordeleau Louise, Mulligan Anna Marie, O'Malley Frances P, Miller Naomi, Andrulis Irene L, Brenner Darren M, Clemons Mark J
Princess Margaret Hospital, Toronto, Canada.
Anticancer Res. 2009 May;29(5):1557-62.
Changes in the receptor profile between primary and metastatic breast cancer tissue have been suggested. The degree of hormone receptor discordance in archival paired pathological samples was evaluated.
Archival data were collected on 100 patients for whom tissue from primary and metastatic sites was available. Estrogen receptor (ER), progesterone receptor (PR) and Her-2/neu status in the primary and metastasis were compared.
The discordance rate for ER was 17.7% (2-sided p=0.0039) with 9.7% of tumours changing from ER-positive to ER-negative and 8.0% changing from ER-negative to ER-positive. The discordance rate for PR was 37.3% (2-sided p<0.0001), with all of these tumours changing from PR-positive to PR-negative. No significant discordance for Her-2/neu was found.
This series suggests that significant discordance exists for hormone receptor status between primary and metastatic breast cancer samples. Loss of PR was particularly frequent.
已有研究表明原发性和转移性乳腺癌组织之间的受体谱存在变化。本研究评估了存档配对病理样本中激素受体不一致的程度。
收集了100例患者的存档数据，这些患者同时有原发性和转移部位的组织样本。比较了原发性肿瘤和转移灶中雌激素受体（ER）、孕激素受体（PR）及Her-2/neu的状态。
ER的不一致率为17.7%（双侧p = 0.0039），其中9.7%的肿瘤从ER阳性变为ER阴性，8.0%从ER阴性变为ER阳性。PR不一致率为37.3%（双侧p < 0.0001），所有这些肿瘤均从PR阳性变为PR阴性。未发现Her-2/neu有显著不一致。
本系列研究表明原发性和转移性乳腺癌样本之间激素受体状态存在显著不一致。PR丢失尤其常见。
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