不可切除的晚期胆管癌患者的治疗——化疗与手术切除

Treatment of patients with unresectable advanced carcinoma of biliary tract - chemotherapy and surgical resection.

作者信息

Morise Zenichi, Sugioka Atsushi, Tanahashi Yoshinao, Okabe Yasuhiro, Ikeda Masahiro, Kagawa Tadashi, Takeura Chinatsu

机构信息

Department of Surgery, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi 470-1192, Japan.

出版信息

Anticancer Res. 2009 May;29(5):1783-6.

PMID:19443404

Abstract

BACKGROUND

The results of 12 consecutive patients with unresectable advanced biliary tract carcinoma treated with first line chemotherapy of S1/cisplatin, combined surgical resection and second line chemotherapy of gemcitabine are evaluated.

PATIENTS AND METHODS

Eight patients with intrahepatic cholangiocarcinoma, 1 with extrahepatic cholangiocarcinoma and 3 with gallbladder carcinoma were included in the study. All patients were treated with S1/cisplatin. Two of the patients underwent combined surgical resection before and 2 after therapy. Second line chemotherapy of gemcitabine was administered in 6 patients.

RESULTS

MST of the patients was 14.9 months. With S1/cisplatin therapy, 6 patients had PR and 4 had SD. Two patients with surgical resection after the therapy survived more than 3 years. Second line chemotherapy of gemcitabine with moderate effects and mild adverse effects was well tolerable.

CONCLUSION

S1/cisplatin showed considerable anti-cancerous effects. Employing surgical resection for patients with good response may lead to the chance of long-term survival.

摘要