CARD8 p.C10X 多态性与早期类风湿关节炎的炎症活动有关。
CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis.
机构信息
Division of Rheumatology, Linköping University Hospital, Linköping, Sweden.
出版信息
Ann Rheum Dis. 2010 Apr;69(4):723-6. doi: 10.1136/ard.2008.106989. Epub 2009 May 13.
OBJECTIVES
CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated.
METHODS
CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in >500 controls and patients with early RA from northern Sweden. The patients were monitored regularly over a 2-year period. The 28-joint disease activity score (DAS28) and its separate components were compared across genotypes.
RESULTS
Patients with one or more variant alleles in CARD8 (CARD8-X) had increased DAS28, tender joint count and erythrocyte sedimentation rate during the 2-year follow-up period despite receiving disease-modifying antirheumatic drugs to a greater extent. CARD8-X was significantly over-represented among patients who received anti-tumour necrosis factor therapy during the first 2 years. CARD8 and NLRP3 genotypes did not influence radiological joint damage and were not associated with an increased susceptibility.
CONCLUSIONS
Carriage of CARD8-X is associated with a worse disease course in early RA.
目的
CARD8 和 NLRP3 是炎性小体的组成部分，可调节白细胞介素 1β 的产生。评估 CARD8 和 NLRP3 多态性对类风湿关节炎（RA）易感性和严重程度的影响。
方法
在瑞典北部的 500 多名早期 RA 患者和对照者中评估 CARD8 p.C10X 和 NLRP3 p.Q705K 基因型。对患者进行了为期 2 年的定期监测。比较不同基因型患者的 28 关节疾病活动评分（DAS28）及其单独组成部分。
结果
尽管接受了更多的疾病修正抗风湿药物治疗，但 CARD8 中存在一个或多个变异等位基因（CARD8-X）的患者在 2 年随访期间 DAS28、压痛关节数和红细胞沉降率增加。在最初 2 年内接受肿瘤坏死因子治疗的患者中，CARD8-X 明显更为常见。CARD8 和 NLRP3 基因型并不影响放射学关节损伤，也与易感性增加无关。
结论
携带 CARD8-X 与早期 RA 的疾病进程恶化有关。
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