Wang Yanping, Xu Nv, Xi Aodeng, Ahmed Zaheer, Zhang Bin, Bai Xiaojia
Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science & Technology, Tianjin, 300457, China.
Appl Microbiol Biotechnol. 2009 Aug;84(2):341-7. doi: 10.1007/s00253-009-2012-x. Epub 2009 May 15.
The objective of this study was to evaluate the effects of Lactobacillus plantarum MA2, an isolate from Chinese traditional Tibet kefir, on cholesterol-lowering and microflora of rat in vivo. Rats were fed on cholesterol-enriched experimental diet, supplemented with lyophilized L. plantarum MA2 powder, with a dose of 10(11) cells/day per mice. The results showed that L. plantarum MA2 feeding significantly lowered serum total cholesterol, low-density lipoprotein cholesterol, and triglycerides level, while there was no change in high-density lipoprotein cholesterol. In addition, liver total cholesterol and triglycerides was also decreased. However, fecal cholesterol and triglycerides was increased significantly (P < 0.05) in comparison with the control. Also, L. plantarum MA2 increased the population of lactic acid bacteria and bifidobacteria in the fecal, but it did not change the number of Escherichia coli as compared to control. Moreover, pH, moisture, and organic acids in the fecal were also measured. The present results indicate the probiotic potential of the L. plantarum MA2 strain in hypocholesterolemic effect and also increasing the probiotic count in the intestine.
本研究的目的是评估从中国传统藏式开菲尔中分离出的植物乳杆菌MA2对大鼠体内降胆固醇作用及微生物区系的影响。给大鼠喂食富含胆固醇的实验饮食，并补充冻干的植物乳杆菌MA2粉末，剂量为每只小鼠每天10(11)个细胞。结果表明，喂食植物乳杆菌MA2可显著降低血清总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平，而高密度脂蛋白胆固醇没有变化。此外，肝脏总胆固醇和甘油三酯也有所降低。然而，与对照组相比，粪便中的胆固醇和甘油三酯显著增加(P < 0.05)。此外，植物乳杆菌MA2增加了粪便中乳酸菌和双歧杆菌的数量，但与对照组相比，大肠杆菌的数量没有变化。此外，还测量了粪便中的pH值、水分和有机酸。目前的结果表明，植物乳杆菌MA2菌株在降胆固醇作用以及增加肠道益生菌数量方面具有益生菌潜力。
