成瘾的可塑性：中脑边缘多巴胺短路？
Plasticity of addiction: a mesolimbic dopamine short-circuit?
作者信息
Niehaus Jason L, Cruz-Bermudez Nelson D, Kauer Julie A
机构信息
Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA.
出版信息
Am J Addict. 2009 Jul-Aug;18(4):259-71. doi: 10.1080/10550490902925946.
Abstract
The development of drug addiction progresses along a continuum from acute drug use to compulsive use and drug seeking behavior. Many researchers have focused on identifying the physiological mechanisms involved in drug addiction in order to develop effective pharmacotherapies. Neuroplasticity, the putative mechanism underlying learning and memory, is modified by drugs of abuse and may contribute to the development of the eventual addicted state. Innovative treatments directly targeting these drug-induced changes in brain reward components and circuits may be efficacious in reducing drug use and relapse.
摘要
药物成瘾的发展是一个连续过程，从急性药物使用发展到强迫性使用和觅药行为。许多研究人员专注于确定药物成瘾所涉及的生理机制，以便开发有效的药物疗法。神经可塑性是学习和记忆的潜在机制，会被滥用药物所改变，并可能促成最终成瘾状态的发展。直接针对这些药物引起的大脑奖赏成分和回路变化的创新疗法，可能在减少药物使用和复发方面有效。
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